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. 1996 May 24;272(5265):1179-82.
doi: 10.1126/science.272.5265.1179.

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

H Shibuya  1 , K Yamaguchi, K Shirakabe, A Tonegawa, Y Gotoh, N Ueno, K Irie, E Nishida, K Matsumoto
Affiliations

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

H Shibuya et al. Science. .

Abstract

Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

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