Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Mar;64(3):1026-9.
doi: 10.1128/iai.64.3.1026-1029.1996.

Platelet-activating-factor-mediated pathogenesis in Lyme disease

E Isogai  1 , K Kimura, N Fujii, T Nishikawa, N Ishii, D Postic, G Baranton, H Isogai
Affiliations

Platelet-activating-factor-mediated pathogenesis in Lyme disease

E Isogai et al. Infect Immun. 1996 Mar.

Abstract

This study describes a role of platelet-activating factor (PAF) as a potential inducer of inflammation in infection with Borrelia burgdorferi. Two approaches were taken. The first involved the use of a PAF antagonist to show the lack of an inflammatory response in skin lesions. The second was to show that the PAF antagonist reduced platelet aggregation when the spirochetes were incubated with polymorphonuclear leukocytes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Science. 1982 Jun 18;216(4552):1317-9 - PubMed
    1. Infect Immun. 1994 Dec;62(12):5559-67 - PubMed
    1. Am J Dermatopathol. 1983 Apr;5(2):111-24 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3534-8 - PubMed
    1. J Infect Dis. 1984 Oct;150(4):497-507 - PubMed

Publication types