Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure

Abstract

Plasma and blood lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD), and serum antioxidant activity (AOA) in uremic patients were examined before and 15 and 30 minutes after the start of dialysis. Hemodialysis was found to produce increased lipid peroxidation in plasma and blood and a simultaneous decrease of SOD activity. The extracellular antioxidant systems were evaluated by the assay of ceruloplasmin level, which did not modify significantly during the dialysis. Our data indicate that the time since the start of dialysis is an important, but not unique factor, influencing possible oxidative damage during hemodialysis.