Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 May 13;9(3):203-11.
doi: 10.1007/BF01796109.

Standard error of immunological dating of evolutionary time

M Nei

Standard error of immunological dating of evolutionary time

M Nei. J Mol Evol. .

Abstract

The empirical variance of the immunological distance as measured by microcomplement fixation with albumin is determined. The variance obtained is at least two times larger than the mean when the mean is small and the ratio of the variance to the mean increases with increasing mean. Thus, the immunological dating of evolutionary time has a large standard error. It is shown that in bird lysozymes the relationship between immunological distance (y) and the number of amino acid substitutions per 100 sites (x) is given by y = 4.2 x approximately.

PubMed Disclaimer

References

    1. Biochem Genet. 1967 Jun;1(1):65-71 - PubMed
    1. Science. 1967 Jan 20;155(3760):279-84 - PubMed
    1. J Mol Evol. 1971;1(1):18-25 - PubMed
    1. J Biol Chem. 1971 Oct 10;246(19):5978-89 - PubMed
    1. Science. 1975 Apr 11;188(4184):107-16 - PubMed

Substances