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. 1996 May 20;386(2-3):91-4.
doi: 10.1016/0014-5793(96)00397-3.

Molecular cloning of a levocabastine-sensitive neurotensin binding site

P Chalon  1 , N Vita, M Kaghad, M Guillemot, J Bonnin, B Delpech, G Le Fur, P Ferrara, D Caput
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Free article

Molecular cloning of a levocabastine-sensitive neurotensin binding site

P Chalon et al. FEBS Lett. .
Free article

Abstract

A search for sequences homologous to the neurotensin receptor cDNA in a rat hypothalamic library has identified a novel neurotensin receptor (NTR-2). The 1539 bp cDNA encodes a 416 amino acid protein and shows highest homology to the previously cloned neurotensin receptor (NTR-1) (64% homology and 43% identity). Binding and pharmacological studies demonstrate that NTR-2 expressed in COS cells recognizes neurotensin (NT) with high affinity as well as several other agonists and antagonists. However, a fundamental difference was found; unlike NTR-1, NTR-2 recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with NT for low-affinity binding sites in brain.

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