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. 1977 May;22(2):446-58.
doi: 10.1128/JVI.22.2.446-458.1977.

Replication process of the parvovirus H-1. IX. Physical mapping studies of the H-1 genome

S L Rhode 3rd

Replication process of the parvovirus H-1. IX. Physical mapping studies of the H-1 genome

S L Rhode 3rd. J Virol. 1977 May.

Abstract

The cleavage map of H-1 replicative-form DNA to the bacterial restriction endonuclease EcoRI, HaeII, HaeIII, HindII, HindIII, and HpaII has been determined. The 5'-phosphoryl end of the viral strand is on the right end of the molecule at or near the replication origin. Evidence is presented for the presence of inverted self-complementary sequences at the right end that differ from those at the left end. These sequences allow a foldback of the DNA after denaturation, and a minority of the native replicative-form DNA has the foldback configuration. The possible role of these structures in H-1 DNA synthesis is discussed.

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References

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    1. Nature. 1976 Sep 9;263(5573):106-9 - PubMed
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