[Prenatal diagnosis of congenital defects through the determination of alpha fetoprotein]
[Article in
German]
- PMID: 86490
Item in Clipboard
[Prenatal diagnosis of congenital defects through the determination of alpha fetoprotein]
[Article in
German]
Fortschr Med.
.
Abstract
The prenatal diagnosis of neural tube defects is based on elevated alpha-fetoprotein (AFP) concentrations in the amniotic fluid as well as in the maternal serum. Amniocentesis has to be performed in those women who already gave birth to an affected child and have the high risk to bear another. On the other hand more than 90% of the newborns with anencephaly and spina bifida are born by mothers without any increased risk in anamnesis. Therefore maternal serum screening is indicated in all pregnant women to rule out a neutral tube defect. The pittfalls of a general serum screening are discussed an a survey of the datas from different international centers is presented.
Similar articles
-
Estimation of the levels of amniotic fluid alpha fetoprotein (AFP) for the prenatal diagnosis of spina bifida and anencephaly.Methods Find Exp Clin Pharmacol. 1981 Nov-Dec;3(6):391-5. Methods Find Exp Clin Pharmacol. 1981. PMID: 6173555
-
Amniotic-fluid alpha-fetoprotein measurement in antenatal diagnosis of anencephaly and open spina bifida in early pregnancy. Second report of the U.K. Collaborative Study on Alpha-fetoprotein in Relation to Neural-tube Defects.Lancet. 1979 Sep 29;2(8144):651-62. Lancet. 1979. PMID: 90757
-
[Prenatal alpha fetoprotein screening for defects in the neural tube].Schweiz Med Wochenschr. 1978 Aug 26;108(34):1302-7. Schweiz Med Wochenschr. 1978. PMID: 80821 German.
-
Alpha-fetoprotein and the prenatal diagnosis of neural tube defects.Obstet Gynecol Annu. 1977;6:173-89. Obstet Gynecol Annu. 1977. PMID: 73159 Review. No abstract available.
-
[Alpha-fetoproteins in obstetrics].Gynakologe. 1983 Sep;16(3):148-54. Gynakologe. 1983. PMID: 6196260 Review. German. No abstract available.
Cited by
-
Maternal serum alpha-fetoprotein screening for neural tube defects. Report of a combined study in Germany and short overview on screening in populations with low birth prevalence of neural tube defects.Hum Genet. 1985;69(1):47-61. doi: 10.1007/BF00295529. Hum Genet. 1985. PMID: 2578423
-
[Alpha-1-fetoprotein screening--development and problems].Soz Praventivmed. 1981 Sep;26(4):217-20. doi: 10.1007/BF02075094. Soz Praventivmed. 1981. PMID: 6171116 German.