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. 1996 Jun 20;381(6584):661-6.
doi: 10.1038/381661a0.

Identification of a major co-receptor for primary isolates of HIV-1

H Deng  1 , R Liu, W Ellmeier, S Choe, D Unutmaz, M Burkhart, P Di Marzio, S Marmon, R E Sutton, C M Hill, C B Davis, S C Peiper, T J Schall, D R Littman, N R Landau
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Identification of a major co-receptor for primary isolates of HIV-1

H Deng et al. Nature. .

Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.

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Comment in

  • Hot fusion of HIV.
    Weiss RA, Clapham PR. Weiss RA, et al. Nature. 1996 Jun 20;381(6584):647-8. doi: 10.1038/381647a0. Nature. 1996. PMID: 8649506 No abstract available.

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