Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jun 20;381(6584):667-73.
doi: 10.1038/381667a0.

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

T Dragic  1 , V Litwin, G P Allaway, S R Martin, Y Huang, K A Nagashima, C Cayanan, P J Maddon, R A Koup, J P Moore, W A Paxton
Affiliations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

T Dragic et al. Nature. .

Abstract

The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4+, non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses.

PubMed Disclaimer

Comment in

  • Hot fusion of HIV.
    Weiss RA, Clapham PR. Weiss RA, et al. Nature. 1996 Jun 20;381(6584):647-8. doi: 10.1038/381647a0. Nature. 1996. PMID: 8649506 No abstract available.

Publication types

MeSH terms

LinkOut - more resources