Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Aug;35(2):229-35.

Split unresponsiveness to trinitrophenyl (TNP) determinant. Suppression of anti-TNP antibody responses by sensitization with picryl chloride

D Rózycka, W Ptak

Split unresponsiveness to trinitrophenyl (TNP) determinant. Suppression of anti-TNP antibody responses by sensitization with picryl chloride

D Rózycka et al. Immunology. 1978 Aug.

Abstract

Contact sensitization by epicutaneous application of picryl chloride causes in mice a significant reduction of the antibody responses to immunogenic TNP-conjugates. This split unresponsiveness is along-lasting. It was found that hapten applied on the skin became attached to the serum proteins and the transfer of such a serum into normal recipients, while not influencing the ability of these animals to become contact-sensitized to PCl, rendered them unable to mount the anti-TNP antibody response. Possible mechanisms of split unresponsiveness to the TNP determinant induced by PCl treatment are suggested.

PubMed Disclaimer

References

    1. Cell Immunol. 1976 Oct;26(2):135-40 - PubMed
    1. J Exp Med. 1975 Nov 1;142(5):1254-62 - PubMed
    1. J Exp Med. 1958 Dec 1;108(6):773-96 - PubMed
    1. Immunology. 1977 May;32(5):743-50 - PubMed
    1. Transplantation. 1972 Jul;14(1):118-24 - PubMed

Publication types

LinkOut - more resources