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. 1995;9(15):1546-51.
doi: 10.1002/rcm.1290091515.

Direct database searching with MALDI-PSD spectra of peptides

P R Griffin  1 , M J MacCoss, J K Eng, R A Blevins, J S Aaronson, J R Yates 3rd
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Direct database searching with MALDI-PSD spectra of peptides

P R Griffin et al. Rapid Commun Mass Spectrom. 1995.

Abstract

The analysis of matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) mass spectra of peptides by using the cross-correlation method for database searching is illustrated. MALDI-PSD mass spectra are shown to contain sufficient fragmentation information to uniquely identify the correct amino acid sequence from large protein databases (approximately 160,000 entries). A search employing the MALDI-PSD mass spectrum of a phosphorylated peptide that correctly identifies the amino acid sequence and the site of phosphorylation is also illustrated.

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