[The immunotherapy of bladder tumors and the immunoprophylaxis of disease recurrence]

Abstract

Therapeutic and preventive effects have been analysed for 84 patients with superficial bladder cancer treated with BCG vaccine. The degree of cell infiltration of the tumor stroma served as a criterion of treatment efficacy and prognosis of recurrence. This degree diminished with augmentation of morphological changes this indicating depression of immunity while tumor formation and increased directly in BCG immunotherapy. In the absence of cell infiltration in response to immunotherapy recurrences become more likely. Preventive and therapeutic use of BCG vaccine in patients with surface tumors of the bladder reduced the number of recurrences 3.6-fold.