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. 1979 Jan;73(1):49-60.
doi: 10.1085/jgp.73.1.49.

Reflection coefficients of homopore membranes: effect of molecular size and configuration

J S Schultz, R Valentine, C Y Choi

Reflection coefficients of homopore membranes: effect of molecular size and configuration

J S Schultz et al. J Gen Physiol. 1979 Jan.

Abstract

Osmotic water flow through membranes with uniform defined pores was measured for a variety of macromolecular solutes. Water flow increased linearly with applied hydrostatic pressure, allowing the effective osmotic pressure of the solutes to be estimated by extrapolation. Reflection coefficients for each solute-membrane combination were calculated and correlated with the ratio of solute size to pore size. For the same mean molecular size, proteins were found to have larger reflection coefficients than dextrans. Molecular rigidity may play a role in this difference in behavior.

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