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. 1996 Feb 15;314 ( Pt 1)(Pt 1):27-32.
doi: 10.1042/bj3140027.

A cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

K Cain  1 , S H Inayat-Hussain, C Couet, G M Cohen
Affiliations

A cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

K Cain et al. Biochem J. .

Abstract

Apoptosis induced in primary hepatocytes by transforming growth factor beta1 and staurosporine produced chromatin condensation, DNA cleavage is detected by in situ end-labelling, field inversion and conventional gel electrophoresis, and cell detachment. These effects were abolished by benzyloxycarbonyl-valinylalanylaspartylfluoromethyl ketone, a cleavage-site-directed inhibitor of interleukin-1beta-converting enzyme-like proteases, and this finding suggests that these enzymes are involved in liver apoptosis.

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References

    1. FEBS Lett. 1994 Aug 8;349(3):385-91 - PubMed
    1. Biochem Cell Biol. 1993 Sep-Oct;71(9-10):488-500 - PubMed
    1. Nature. 1994 Sep 22;371(6495):346-7 - PubMed
    1. Exp Cell Res. 1994 Dec;215(2):332-7 - PubMed
    1. J Biol Chem. 1994 Dec 9;269(49):30761-4 - PubMed

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