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. 1996 Apr 5;221(1):151-6.
doi: 10.1006/bbrc.1996.0561.

Abnormal behavior and neurotransmissions of tenascin gene knockout mouse

F Fukamauchi  1 , N Mataga, Y J Wang, S Sato, A Youshiki, M Kusakabe
Affiliations

Abnormal behavior and neurotransmissions of tenascin gene knockout mouse

F Fukamauchi et al. Biochem Biophys Res Commun. .

Abstract

To examine the role of tenascin (TN) in vivo, we have produced mice in which the TN gene is inactivated. In behavioral studies, TN-knockout mice showed abnormal behavior such as hyperlocomotion and poor swimming ability. Biochemical analysis revealed that serotonin (5-HT) and dopamine (DA) transmission was decreased in the cerebral cortex, the hippocampus, or the striatum of TN-knockout mouse brain. The intraperitoneal administration of the DA receptor agonist, LY171555 (0.5 mg/kg, BW), inhibited the hyperlocomotion, and swimming behavior was transiently improved by the treatment with the 5-HT receptor agonist, 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride. These findings suggest that TN may play an important role in neurotransmissions related to behavior.

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