Enhanced expression of manganese superoxide dismutase mRNA and increased TNFalpha mRNA expression by gastric mucosa in gastric cancer
- PMID: 8661822
- DOI: 10.1007/s002689900035
Enhanced expression of manganese superoxide dismutase mRNA and increased TNFalpha mRNA expression by gastric mucosa in gastric cancer
Abstract
Manganese superoxide dismutase (Mn-SOD), a mitochondrial enzyme, is a cytokine-regulated acute-phase protein that protects cells from free radicals. The current investigations examined the in vivo regulation of the expression of Mn-SOD mRNA and tumor necrosis factor alpha (TNFalpha) mRNA in gastric carcinoma tissue. The expression of these transcripts in breast carcinoma tissue also was examined because breast cancer is a much more TNF-sensitive tumor than gastric cancer. TNFalpha mRNA was markedly increased in gastric carcinoma tissue (p < 0.005). There were significantly higher levels of Mn-SOD mRNA in gastric carcinoma tissue than in noncancerous tissue (p < 0.0001). The level of Mn-SOD mRNA in gastric carcinoma tissue was higher than that in breast carcinoma tissue (p < 0.005). Up-regulation of Mn-SOD mRNA in gastric carcinoma tissue most likely serves as a protective mechanism against superoxide radicals and TNF cytotoxicity.
Similar articles
-
Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas.Int J Oncol. 2000 Jul;17(1):107-12. doi: 10.3892/ijo.17.1.107. Int J Oncol. 2000. PMID: 10853026
-
[Use of the PCR in the quantitation of Mn-SOD and TNF-alpha mRNA expression by gastric mucosa in gastric cancer].Nihon Shokakibyo Gakkai Zasshi. 1994 Nov;91(11):2151. Nihon Shokakibyo Gakkai Zasshi. 1994. PMID: 7815736 Japanese. No abstract available.
-
Tumor necrosis factor-alpha increases Mn-SOD expression: protection against oxidant injury.Am J Physiol. 1991 Apr;260(4 Pt 1):L296-301. doi: 10.1152/ajplung.1991.260.4.L296. Am J Physiol. 1991. PMID: 1850207
-
Activation of genes for superoxide dismutase, interleukin-1beta, tumor necrosis factor-alpha, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury.Scand J Gastroenterol. 2000 May;35(5):452-63. doi: 10.1080/003655200750023697. Scand J Gastroenterol. 2000. PMID: 10868446
-
Differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase in the rat corpus luteum: induction of manganese superoxide dismutase messenger ribonucleic acid by inflammatory cytokines.Biol Reprod. 1998 Jul;59(1):208-15. doi: 10.1095/biolreprod59.1.208. Biol Reprod. 1998. PMID: 9675014
Cited by
-
Efficacy of Omega Fatty Acid Supplementation on mRNA Expression Level of Tumor Necrosis Factor Alpha in Patients with Gastric Adenocarcinoma.J Gastrointest Cancer. 2016 Sep;47(3):287-93. doi: 10.1007/s12029-016-9826-4. J Gastrointest Cancer. 2016. PMID: 27170003
-
Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population.World J Gastroenterol. 2004 May 1;10(9):1256-61. doi: 10.3748/wjg.v10.i9.1256. World J Gastroenterol. 2004. PMID: 15112338 Free PMC article.
-
The study of chemiluminescence in gastric and colonic carcinoma cell lines treated by anti-tumor drugs.World J Gastroenterol. 2003 Feb;9(2):242-5. doi: 10.3748/wjg.v9.i2.242. World J Gastroenterol. 2003. PMID: 12532439 Free PMC article.
-
The resistance of esophageal adenocarcinoma to bile salt insult is associated with manganese superoxide dismutase expression.J Surg Res. 2011 Dec;171(2):623-30. doi: 10.1016/j.jss.2010.04.038. Epub 2010 May 21. J Surg Res. 2011. PMID: 20638682 Free PMC article.
-
Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study.BMC Cancer. 2012 Dec 22;12:617. doi: 10.1186/1471-2407-12-617. BMC Cancer. 2012. PMID: 23259684 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical