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. 1977 Apr;4(4):843-52.
doi: 10.1093/nar/4.4.843.

CD studies on ribonuclease A - oligonucleotides interactions

M D White, M Keren-Zur, Y Lapidot
Free PMC article

CD studies on ribonuclease A - oligonucleotides interactions

M D White et al. Nucleic Acids Res. 1977 Apr.
Free PMC article

Abstract

The interaction of ApU, Aps4U, Aps4Up, ApAps4Up and Gps4U with RNase A was studied by CD difference spectroscopy. The use of 4-thiouridine (s4U) containing oligonucleotides enables to distinguish between the interaction of the different components of the ligand with the enzyme. The mode of binding of the oligonucleotides to the enzyme is described. From this mode of binding it is explained why Aps4U, for example, inhibits RNase A, while s4UpA serves as a substrate.

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