doi: 10.1126/science.273.5274.494.
Multicolor spectral karyotyping of human chromosomes
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- PMID: 8662537
- DOI: 10.1126/science.273.5274.494
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Multicolor spectral karyotyping of human chromosomes
Science.
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Abstract
The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.
Comment in
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New methods for expanding the chromosomal paint kit.Science. 1996 Jul 26;273(5274):430. doi: 10.1126/science.273.5274.430. Science. 1996. PMID: 8677436 No abstract available.
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