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. 1996 Apr 1;183(4):1731-7.
doi: 10.1084/jem.183.4.1731.

The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression

U Grawunder  1 , D G Schatz, T M Leu, A Rolink, F Melchers
Affiliations

The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression

U Grawunder et al. J Exp Med. .

Abstract

Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.

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