Posttransplantation lymphoproliferative disorders (PTLD): current perspectives

Abstract

Posttransplant lymphoproliferative disorders (PTLDs) are a family of lymphoid hyperplasias and neoplasias that occur in the context of organ transplantation and immunosuppression. A strong association exists with Epstein-Barr virus (EBV) infection of the B lymphocyte. This review summarizes clinical and pathological aspects of these lesions and explains the terminology used to describe them. Clinical diagnosis and therapy, including experimental approaches, are outlined. Patient outcomes from published series are given. The clinical heterogeneity and the need to individualize therapy for these patients are stressed.