Review
[Genetics and endocrinology of male sex differentiation: application to molecular study of male pseudohermaphroditism]
[Article in
French]
Affiliations
- PMID: 8673622
Item in Clipboard
Review
[Genetics and endocrinology of male sex differentiation: application to molecular study of male pseudohermaphroditism]
[Article in
French]
C R Seances Soc Biol Fil.
1995.
Abstract
The various processes involved in sexual differentiation have been considerably clarified over the last few years through advances in biochemistry and molecular genetics. The cloning of the gene responsible for testicular determination SRY, of the anti-Müllerian hormone and anti-Müllerian hormone receptor genes, of the several steroidogenic enzymes genes, of the 5 alpha-reductase type 2 gene and of the androgen receptor gene has permitted to elucidate the molecular defects causing abnormal sexual differentiation. These data have brought a substantial impact on the understanding of human male sexual differentiation and its main disorders.
Similar articles
-
[Normal sexual differentiation: molecular genetic and endocrinology].C R Seances Soc Biol Fil. 1992;186(4):314-31. C R Seances Soc Biol Fil. 1992. PMID: 1301219 Review. French.
-
[Male pseudohermaphroditism].Tanpakushitsu Kakusan Koso. 1988 Apr;33(5):912-8. Tanpakushitsu Kakusan Koso. 1988. PMID: 3270909 Japanese. No abstract available.
-
Abnormal sexual differentiation: male pseudohermaphroditism (MPH) and abnormal steroid synthesis metabolism and action.Prog Clin Biol Res. 1985;171:175-206. Prog Clin Biol Res. 1985. PMID: 3983185 No abstract available.
-
[Male pseudohermaphroditism].Pediatr Med Chir. 1985 Jul-Aug;7(4):481-6. Pediatr Med Chir. 1985. PMID: 3837212 Italian.
-
Classification of hereditary disorders of sexual development.Birth Defects Orig Artic Ser. 1975;11(4):1-16. Birth Defects Orig Artic Ser. 1975. PMID: 1098701 Review. No abstract available.
Cited by
-
Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study.Life (Basel). 2023 Nov 1;13(11):2152. doi: 10.3390/life13112152. Life (Basel). 2023. PMID: 38004292 Free PMC article.
-
The Impact of 5α-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health.Curr Urol Rep. 2018 Jun 16;19(8):65. doi: 10.1007/s11934-018-0814-z. Curr Urol Rep. 2018. PMID: 29909472 Review.