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. 1996 Jul;70(7):4816-8.
doi: 10.1128/JVI.70.7.4816-4818.1996.

Evidence that the nuclease activities associated with the herpes simplex type 1 DNA polymerase are due to the 3'-5' exonuclease

J D Hall  1 , K L Orth, D Claus-Walker
Affiliations

Evidence that the nuclease activities associated with the herpes simplex type 1 DNA polymerase are due to the 3'-5' exonuclease

J D Hall et al. J Virol. 1996 Jul.

Abstract

We investigated nuclease activities associated with the catalytic subunit of herpes simplex virus type 1 DNA polymerase. We confirm that a 3'-5' exonuclease copurifies with this enzyme. Previous reports suggested that a 5' DNase was intrinsic to the polymerase. Our preparation lacks such activity.

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