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. 1996 Jul;70(7):4858-63.
doi: 10.1128/JVI.70.7.4858-4863.1996.

An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death

C L Afonso  1 , J G Neilan, G F Kutish, D L Rock
Affiliations

An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death

C L Afonso et al. J Virol. 1996 Jul.

Abstract

Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.

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