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. 1996;95(3-4):218-23.
doi: 10.1159/000203881.

Expression and signal transduction of the FLT3 tyrosine kinase receptor

O Rosnet  1 , H J Bühring, O deLapeyrière, N Beslu, C Lavagna, S Marchetto, I Rappold, H G Drexler, F Birg, R Rottapel, C Hannum, P Dubreuil, D Birnbaum
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Expression and signal transduction of the FLT3 tyrosine kinase receptor

O Rosnet et al. Acta Haematol. 1996.

Abstract

FLT3 is a receptor tyrosine kinase of 130-55 kDa expressed on normal bone marrow stem and early progenitor cells and on leukemic blasts from patients with acute leukemias. The FLT3 ligand, FL, is a new cytokine which acts on hematopoietic progenitors in synergy with other cytokines. FLT3 transduces FL-mediated signal through interaction with a number of cytoplasmic substrates.

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