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. 1996;141(5):857-64.
doi: 10.1007/BF01718160.

Anti-EBNA1/anti-EBNA2 ratio decreases significantly in patients with progression of HIV infection

B Winkelspecht  1 , F Grässer, H W Pees, N Mueller-Lantzsch
Affiliations

Anti-EBNA1/anti-EBNA2 ratio decreases significantly in patients with progression of HIV infection

B Winkelspecht et al. Arch Virol. 1996.

Abstract

Reactivation of EBV infection is common in immunocompromised individuals. We determined specific antibodies to EBV-encoded nuclear antigens (EBNA)1 and 2 in 102 sera of HIV-infected individuals. Anti-EBNA1/anti-EBNA2 ratio (E1/E2) is less than 1 in chronic infection and exceeds 1 in healthy EBV-positive carriers. 52% of cases had E1/E2 < 1. E1/E2 decreased remarkably during the progression of HIV infection. Detectable HIV-Antigen, decline of CD4+ cell count and CD4+/CD8+ ratio were correlated with an increasing prevalence of E1/E2 below 1. We conclude that determination of E1/E2 is useful in immunocompromised patients.

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