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Comparative Study
. 1996 Aug;7(8):575-9.
doi: 10.1007/s003359900172.

Comparative mapping on the mouse X chromosome defines a myotubular myopathy equivalent region

B de Gouyon  1 , A Chatterjee, A Monaco, N Quaderi, S D Brown, G E Herman
Affiliations
Comparative Study

Comparative mapping on the mouse X chromosome defines a myotubular myopathy equivalent region

B de Gouyon et al. Mamm Genome. 1996 Aug.

Abstract

The gene for X-linked myotubular myopathy (MTM1) has been localized to a 300-kb critical region in human Xq28 between IDS and GABRA3. As part of an effort to clone this gene, we developed a YAC contig on the mouse X Chromosome (Chr) which includes loci homologous to those within the human MTM1 critical region. The murine contig consists of 18 YACs and spans 2.5-3.0 Mb. We have aligned the human and murine physical maps by isolating conserved mouse genomic fragments, including CpG islands and trapped exons. We believe that the simultaneous isolation of genes from both mouse and human and continued comparative mapping will prove helpful in the eventual identification of MTM1 and other genes in the region.

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