[Effect of puerarin on cerebral blood flow in dogs]

Abstract

The hemodynamics of left intra- and extracranial arteries was determined by a pulsatile Doppler flowmeter and a transcranial Doppler system simultaneously in anesthetized dogs. Low doses of puerarin (50mg/kg, iv) did not alter the cerebral perfusion pressure, but reduced the flow velocities of both middle cerebral artery and anterior cerebral artery. The globle cerebral blood flow was enhanced due to dilatation of the intracranial arteries.