Review
doi: 10.1016/0952-7915(95)80046-8.
Antagonizing the differentiation and functions of human T helper type 2 cells
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- PMID: 8679118
- DOI: 10.1016/0952-7915(95)80046-8
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Review
Antagonizing the differentiation and functions of human T helper type 2 cells
Curr Opin Immunol.
1995 Dec.
Abstract
Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-helper type 2 cells suggest that targeting allergen-specific T cells may provide a novel way to intervene in allergy.
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