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. 1996 Jul;98(1):16-21.
doi: 10.1007/s004390050153.

Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation

M A Weterman  1 , M Wilbrink, T Dijkhuizen, E van den Berg, A Geurts van Kessel
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Free article

Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation

M A Weterman et al. Hum Genet. 1996 Jul.
Free article

Abstract

A combination of Southern blot analysis on a panel of tumor-derived somatic cell hybrids and fluorescence in situ hybridization (FISH) techniques was used to map a series of DNA markers relative to the 1q21 breakpoint of the renal cell carcinoma (RCC)-associated (X;1)-(p11;q21) translocation. This breakpoint maps between several members of the S100 family which are clustered in the 1q21 region and a conserved region between man and mouse containing the markers SPTA1-CRP-APCS-FcER1A-ATP1A2-APOA2. The location of the breakpoint coincides with the transition of a region of synteny of human chromosome 1 with mouse chromosomes 3 and 1.

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