Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jun:77 ( Pt 6):1163-8.
doi: 10.1099/0022-1317-77-6-1163.

Transcriptional analysis of the Epstein-Barr virus interleukin-10 homologue during the lytic cycle

R Touitou  1 , C Cochet, I Joab
Affiliations

Transcriptional analysis of the Epstein-Barr virus interleukin-10 homologue during the lytic cycle

R Touitou et al. J Gen Virol. 1996 Jun.

Abstract

The Epstein-Barr virus (EBV) open reading frame (ORF) BCRF1, expressed in the late phase of the viral cycle, encodes a homologue of human interleukin-10 (hIL-10). Unspliced, 3' co-terminal transcripts of 0.8 and 1.6 kb from O-tetradecanoylphorbol 13-acetate (TPA)-treated B95-8 cells have been described but other results indicated the existence of uncharacterized transcript(s) initiated upstream of the 1.6 kb BCRF1 mRNA. Here we describe two additional large transcripts of the BCRF1 ORF, a possibly spliced product of 3.5 kb and an unspliced product of 4.5 kb. The time course of the expression of BCRF1 transcripts and of the secreted protein from Akata cells were also determined.

PubMed Disclaimer

Publication types

LinkOut - more resources