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Case Reports
. 1995;122(10):701-3.

[Lichen planus and vaccination against hepatitis B]

[Article in French]
A Lefort  1 , D Dachary, B Vergier, G Boiron
Affiliations
  • PMID: 8687059
Case Reports

[Lichen planus and vaccination against hepatitis B]

[Article in French]
A Lefort et al. Ann Dermatol Venereol. 1995.

Abstract

Introduction: The association of lichen planus with liver diseases is now well established. Lichen planus following hepatitis B vaccination are much more unusual. We report here the fifth case of this kind.

Case report: A 16 years old girl developed a purely cutaneous lichen planus one week after the first injection of hepatitis B vaccine Gen Hevac B (Institut Pasteur), which appeared again 3 days after the second injection. The histologic features shown lichenoid pattern with intense keratinocytes necrosis more in favor of lichenoid drug eruption than lichen planus.

Discussion: According to our knowledge, only four similar cases have been previously reported. Comparison between the different vaccines used shows that only the HBs antigen and its epitope S could be involved in the lichen planus eruption. Our case is specific due to the early appearance of the eruption after the first injection and by its histologic features.

Conclusion: New cases of lichen planus following hepatitis B vaccination should help to explain the causal relationship between lichen planus eruption and hepatitis B vaccination.

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