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. 1996 Jun 1;316 ( Pt 2)(Pt 2):385-7.
doi: 10.1042/bj3160385.

Evidence that biliverdin-IX beta reductase and flavin reductase are identical

F Shalloe  1 , G Elliott, O Ennis, T J Mantle
Affiliations

Evidence that biliverdin-IX beta reductase and flavin reductase are identical

F Shalloe et al. Biochem J. .

Abstract

A search of the database shows that human biliverdin-IX beta reductase and flavin reductase are identical. We have isolated flavin reductase from bovine erythrocytes and show that the activity co-elutes with biliverdin-IX beta reductase. Preparations of the enzyme that are electrophoretically homogeneous exhibit both flavin reductase and biliverdin-IX beta reductase activities; however, they are not capable of catalysing the reduction of biliverdin-IX alpha. Although there is little obvious sequence identity between biliverdin-IX alpha reductase (BVR-A) and biliverdin-IX beta reductase (BVR-B), they do show weak immunological cross-reactivity. Both enzymes bind to 2',5'-ADP-Sepharose.

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