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. 1996 Jan;4(1):81-90.
doi: 10.1016/0968-0896(95)00173-5.

Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties

P Barraclough  1 , M L Bolofo, H Giles, J Gillam, C J Harris, M G Kelly, P Leff, A McNeill, A D Robertson, R J Stepney, B J Whittle
Affiliations

Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties

P Barraclough et al. Bioorg Med Chem. 1996 Jan.

Abstract

The rationale for investigating conformationally restricted analogues of BW245C as DP-receptor ligands and the syntheses of three such racemic bicyclic imidazolidinone analogues are described. Compounds 7 (BW587C), 8 (BW480C85), and 9 (BW572C85) were found to be potent inhibitors of human platelet aggregation and selective DP-receptor agonists in washed platelet and jugular vein isolated tissue assays.

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