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Case Reports
. 1996 Jul 1;89(1):1-6.
doi: 10.1016/0165-4608(95)00300-2.

dup(10q) lacking alpha-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia

D Abeliovich  1 , O Yehuda, S Ben-Neriah, Y Kapelushnik, D Ben-Yehuda
Affiliations
Case Reports

dup(10q) lacking alpha-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia

D Abeliovich et al. Cancer Genet Cytogenet. .

Abstract

A marker chromosome was identified in leukemic cells on an AML patient. The G-banding pattern resembled on i(10q), but its centromeric position was not clear; in some cells it had a telocentric shape, in others a metacentric or acentric shape. The origin of the marker chromosome was confirmed by FISH, using chromosome-10-specific painting. To determine the centromeric position, C-banding and alpha-satellite probes were applied in FISH, and none of them gave a positive signal. Despite the absence of the centromeric alpha-satellite sequences and the constricted feature of the centromere, the essential centromeric activity was retained in this chromosome, namely, the separation of sister chromatids in anaphase.

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