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Case Reports
. 1996 Jul 1;89(1):61-4.
doi: 10.1016/0165-4608(95)00350-9.

Loss of an X chromosome in aggressive angiomyxoma of female soft parts: a case report

M B Kenny-Moynihan  1 , J Hagen, B Richman, D G McIntosh, J A Bridge
Affiliations
Case Reports

Loss of an X chromosome in aggressive angiomyxoma of female soft parts: a case report

M B Kenny-Moynihan et al. Cancer Genet Cytogenet. .

Abstract

Cytogenetic analysis of an aggressive angiomyxoma of the vulvar region of a 16-year-old female revealed loss of one X chromosome (45,X,-X) in eight of 20 metaphase cells analyzed. Fluorescence in situ hybridization (FISH) performed on disaggregated cells from paraffin embedded lesional tissue confirmed loss of an X chromosome in 31% of cells. Cytogenetic analysis performed on peripheral blood showed a normal chromosomal complement (46,XX). Thus, loss of one X chromosome appears to be confined to the neoplasm. This anomaly has not been previously described in aggressive angiomyxoma.

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