Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jun;88(2):183-90.
doi: 10.1111/j.1365-2567.1996.tb00003.x.

Recognition of CD52 allelic gene products by CAMPATH-1H antibodies

C Hale  1 , M Bartholomew, V Taylor, J Stables, P Topley, J Tite
Affiliations

Recognition of CD52 allelic gene products by CAMPATH-1H antibodies

C Hale et al. Immunology. 1996 Jun.

Abstract

Cloning of the CD52 from a B-lymphocyte tumour cDNA library revealed two closely related sequences differing only at two amino acids C-terminal to the proposed point of glycosylphosphatidylinositol (GPI)-linkage. When transfected into CHO cells only one of these sequences gave high-level expression of the antigen recognized by the prototypic anti-CD52 antibody CAMPATH-1 whereas in JURKAT cells good expression levels were obtained with both sequences. Fusion of the sequence from the second sequence to DNA encoding the extracellular domain of CD4 indicated that this sequence was capable of directing GPI linkage. The possible implications for the function of CD52 and serotherapy with anti-CD52 antibodies are discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Eur J Immunol. 1991 Jul;21(7):1677-84 - PubMed
    1. J Cell Biol. 1991 Dec;115(6):1595-600 - PubMed
    1. J Immunol. 1992 Feb 1;148(3):672-7 - PubMed
    1. Lancet. 1992 Sep 26;340(8822):748-52 - PubMed
    1. J Immunol. 1992 Dec 1;149(11):3535-41 - PubMed

MeSH terms