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Review
. 1996 Jun;59(6):784-8.
doi: 10.1002/jlb.59.6.784.

Membrane phospholipid asymmetry: host response to the externalization of phosphatidylserine

E M Bruckheimer  1 , A J Schroit
Affiliations
Review

Membrane phospholipid asymmetry: host response to the externalization of phosphatidylserine

E M Bruckheimer et al. J Leukoc Biol. 1996 Jun.

Abstract

Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.

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