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. 1977 Feb;10(2):167-70.

[Toxic hepatitis caused by rifampin and isoniazid in treatment of tuberculosis (author's transl)]

[Article in Spanish]
G Abeledo Mezquita, M C Otero Reigada
  • PMID: 869341

[Toxic hepatitis caused by rifampin and isoniazid in treatment of tuberculosis (author's transl)]

[Article in Spanish]
G Abeledo Mezquita et al. An Esp Pediatr. 1977 Feb.

Abstract

Five children with tuberculosis were treated with isoniazid (20 mg./Kg./day) and rifampin (15 mg./Kg./day). After five to twenty seven days of treatment they presented anorexia, vomiting and jaundice. Hepatomegaly was found in two of them. High indirect bilirubin, S.G.O.T. and S.G.P.T. and low prothrombin levels were present in all of them. Eight to thirty one days after withdrawal of rifampin, all patients were well and their laboratory data was normal.

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