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Review
. 1996 Feb;6(1):11-7.
doi: 10.1016/s0959-440x(96)80089-3.

Alternative conformations of amyloidogenic proteins govern their behavior

J W Kelly  1
Affiliations
Review

Alternative conformations of amyloidogenic proteins govern their behavior

J W Kelly. Curr Opin Struct Biol. 1996 Feb.

Abstract

Recent publications strongly support the hypothesis that conformational changes in amyloidogenic proteins lead to amyloid fibril formation and cause disease. Biophysical studies on several amyloidogenic proteins provide insights into the conformational changes required for fibrilogenesis. In addition, newly available moderate to high resolution structural studies are bringing us closer to understanding the structure of amyloid.

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