doi: 10.1016/0742-8413(96)00002-3.
Effects of an acute dose of ethanol on dopaminergic and serotonergic systems from rat cerebral cortex and striatum
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- PMID: 8697197
- DOI: 10.1016/0742-8413(96)00002-3
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Effects of an acute dose of ethanol on dopaminergic and serotonergic systems from rat cerebral cortex and striatum
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol.
1996 Mar.
Abstract
Intraperitoneal injection 10 min before sacrifice of 1.5 g ethanol/kg weight produced an increase in rat striatal levels of homovanillic acid (HVA) (p < 0.05) but did not affect the striatal concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). A similar ethanol treatment led to decreases in 5-HT (p < 0.05) and 5-HIAA (p < 0.05) from cerebral cortex (prefrontal and anterior cingulate areas). The results point to several ethanol-linked alterations in central serotonergic and dopaminergic systems.
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