Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Mar;113(3):399-402.
doi: 10.1016/0742-8413(96)00002-3.

Effects of an acute dose of ethanol on dopaminergic and serotonergic systems from rat cerebral cortex and striatum

E Gil-Martín  1 , I Colado, A Fernández-López, A Fernández-Briera, P Calvo
Affiliations

Effects of an acute dose of ethanol on dopaminergic and serotonergic systems from rat cerebral cortex and striatum

E Gil-Martín et al. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Mar.

Abstract

Intraperitoneal injection 10 min before sacrifice of 1.5 g ethanol/kg weight produced an increase in rat striatal levels of homovanillic acid (HVA) (p < 0.05) but did not affect the striatal concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). A similar ethanol treatment led to decreases in 5-HT (p < 0.05) and 5-HIAA (p < 0.05) from cerebral cortex (prefrontal and anterior cingulate areas). The results point to several ethanol-linked alterations in central serotonergic and dopaminergic systems.

PubMed Disclaimer

Publication types