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. 1996 Jul;64(7):2821-3.
doi: 10.1128/iai.64.7.2821-2823.1996.

T- and B-lymphocyte-independent formation of alveolar macrophage-derived multinucleated giant cells in murine Pneumocystis carinii pneumonia

R Hanano  1 , K Reifenberg, S H Kaufmann
Affiliations

T- and B-lymphocyte-independent formation of alveolar macrophage-derived multinucleated giant cells in murine Pneumocystis carinii pneumonia

R Hanano et al. Infect Immun. 1996 Jul.

Abstract

Multinucleated giant cells developed in Pneumocystis carinii-diseased gene disruption mutant mice deficient in major histocompatibility complex class II molecules, T-cell receptor alpha beta cells, or all mature T and B lymphocytes. These findings demonstrate lymphocyte-independent fusion of alveolar macrophages under morbid conditions. Pulmonary parasite burden seems to be a decisive factor in multinucleation.

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