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. 1996 Jul;64(7):2824-8.
doi: 10.1128/iai.64.7.2824-2828.1996.

Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

P J Brett  1 , D E Woods
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Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

P J Brett et al. Infect Immun. 1996 Jul.

Abstract

The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.

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