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. 1996 Jul;64(7):2824-8.
doi: 10.1128/iai.64.7.2824-2828.1996.

Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

P J Brett  1 , D E Woods
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Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

P J Brett et al. Infect Immun. 1996 Jul.

Abstract

The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.

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References

    1. Infect Immun. 1995 Sep;63(9):3348-52 - PubMed
    1. Lancet. 1994 Nov 12;344(8933):1359 - PubMed
    1. Can J Microbiol. 1976 Jan;22(1):29-34 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 - PubMed
    1. J Immunol. 1981 Sep;127(3):1011-8 - PubMed

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