Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jul;64(7):2850-2.
doi: 10.1128/iai.64.7.2850-2852.1996.

Interleukin-10 protects neonatal mice from lethal group B streptococcal infection

V Cusumano  1 , F Genovese, G Mancuso, M Carbone, M T Fera, G Teti
Affiliations

Interleukin-10 protects neonatal mice from lethal group B streptococcal infection

V Cusumano et al. Infect Immun. 1996 Jul.

Abstract

We investigated the role of interleukin-10 (IL-10) in a neonatal mouse model of lethal group B streptococci (GBS) sepsis. Plasma IL-10 levels significantly increased at 24 and 48 h after GBS inoculation. Neutralization of IL-10 with specific antibodies had no effect on lethality. Administration of recombinant IL-10 at 20 or 4 h before challenge, but not at later times, resulted in decreased tumor necrosis factor alpha levels and improved survival. IL-10 could be potentially useful for the treatment of GBS sepsis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. N Engl J Med. 1986 Jun 26;314(26):1702-4 - PubMed
    1. J Inflamm. 1995;45(1):13-26 - PubMed
    1. J Exp Med. 1989 Dec 1;170(6):2081-95 - PubMed
    1. J Immunol. 1990 Nov 1;145(9):2938-45 - PubMed
    1. Int Immunol. 1990;2(9):821-32 - PubMed

Publication types

MeSH terms