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Case Reports
. 1996 Aug;174(2):407-10.
doi: 10.1093/infdis/174.2.407.

Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome

A Antoniadis  1 , A Stylianakis, A Papa, S Alexiou-Daniel, A Lampropoulos, S T Nichol, C J Peters, C F Spiropoulou
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Case Reports

Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome

A Antoniadis et al. J Infect Dis. 1996 Aug.

Abstract

Blood samples were collected from an Albanian and a Greek patient with hemorrhagic fever with renal syndrome and tested by reverse transcriptase-polymerase chain reaction. The genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the blood of the patients; nucleotide sequence analysis revealed that the causative agent of the disease was Dobrava virus. These findings suggest that Dobrava virus (which was originally isolated from the lungs of an Apodenws flavicollis mouse in Slovenia) is endemic throughout the Balkan States and causes overt human disease.

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Comment in

  • Tracing Dobrava hantavirus infection.
    Papa A, Spiropoulou C, Nichol S, Antoniadis A. Papa A, et al. J Infect Dis. 2000 Jun;181(6):2116-7. doi: 10.1086/315491. J Infect Dis. 2000. PMID: 10837207 No abstract available.

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