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. 1996 Feb;27(2):157-62.
doi: 10.1007/BF00177479.

Interstitial chemotherapy with mitoxantrone in recurrent malignant glioma: preliminary data

A Boiardi  1 , A Salmaggi, A Pozzi, G Broggi, A Silvani
Affiliations

Interstitial chemotherapy with mitoxantrone in recurrent malignant glioma: preliminary data

A Boiardi et al. J Neurooncol. 1996 Feb.

Abstract

We undertook a phase I-II trail of loco-regional mitoxantrone in 12 patients affected by malignant gliomas. Mitoxantrone was delivered at tumor recurrence by Ommaya reservoir, with 2 cycles and a 1 month interval between each cycle, in conjunction with systemic chemotherapy (8 pts) or not (4 pts). Treatment tolerability was good, and 9 of the patients showed either response or stable disease at the end of the treatment schedule. Regardless of associated chemotherapy, time to further tumor progression was at 6 months. A combination of early systemic and loco-regional chemotherapy with surgery and radiotherapy seems worth while pursuing in the therapeutic approach to malignant gliomas.

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