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. 1977 May 1;163(2):393-5.
doi: 10.1042/bj1630393.

Different reactivities of free and bound amino groups in deoxy-and liganded haemoglobin

D Bresciani

Different reactivities of free and bound amino groups in deoxy-and liganded haemoglobin

D Bresciani. Biochem J. .

Abstract

The technique of competitive double-labelling [H. Kaplan, K.J. Stevenson & B.S. Hartley, (1971) Biochem. J. 124, 289-299; L.P. Visentin & H. Kaplan (1975) Biochemistry 14, 463-468] was used to determine the reactivity of some amino groups towards acetic anhydride in deoxy-and liganded haemoglobin. Only those amino groups known to form salt bridges in deoxy-but not in liganded haemoglobin (i.e. the alpha-amino group of valine-1 alpha and the xi-amino group of lysine-40 alpha and lysine-127 alpha [M. F. Perutz (1970) Nature (London) 228, 726-739]) and different reactivities in the two structures.

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References

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