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. 1995 Nov;69(3):289-91.
doi: 10.1254/jjp.69.289.

Induction of cyclooxygenase type-2 (COX-2) in rat endometrium at the peak of serum estradiol during the estrus cycle

T Shoda  1 , K Hatanaka, M Saito, M Majima, M Ogino, Y Harada, M Nishijima, M Katori, S Yamamoto
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Free article

Induction of cyclooxygenase type-2 (COX-2) in rat endometrium at the peak of serum estradiol during the estrus cycle

T Shoda et al. Jpn J Pharmacol. 1995 Nov.
Free article

Abstract

We investigated the induction of cyclooxygenase (COX) in rat endometrium during the estrus cycle. The estrus cycle was divided into five stages (proestrus, estrus, diestrus-1, diestrus-2, diestrus-3) by cytological observation of vaginal smears. COX-1 was detected in the endometrium during all five stages of the estrus cycle. In contrast, COX-2 in the endometrium was detectable only in three stages (diestrus-3, proestrus, estrus) and showed a peak at diestrus-3, coinciding with the peak in serum estradiol level, suggesting the estradiol-dependent induction of COX-2.

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