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. 1996 Mar 5;93(5):1820-4.
doi: 10.1073/pnas.93.5.1820.

A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells

P S Andersen  1 , A Stryhn, B E Hansen, L Fugger, J Engberg, S Buus
Affiliations

A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells

P S Andersen et al. Proc Natl Acad Sci U S A. .

Abstract

Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.

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