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Review
. 1990;77(1):15-22.

[Time factor and curietherapy: the example of epidermoid carcinoma of the mobile tongue]

[Article in French]
J J Mazeron  1 , F Mornex
Affiliations
  • PMID: 8703538
Review

[Time factor and curietherapy: the example of epidermoid carcinoma of the mobile tongue]

[Article in French]
J J Mazeron et al. Bull Cancer Radiother. 1990.

Abstract

Experimental evidence exists of a dose-rate effect relationship in low dose continuous irradiation of cell population. In 1952, Paterson drew from his clinical experience on radium 226 implant, a dose-time iso-effect curve. Several authors, reviewing series of squamous cell carcinomas of the mobile tongue, implanted by radium 226 or iridium 192, did not confirm Paterson's hypothesis. Recently, a retrospective analysis of T1 and T2 squamous cell carcinomas, all treated exclusively by iridium 192 at the Henri-Mondor Hospital (Créteil, France), suggested a possible dose-rate effect relationship below 1 Gy/h. However, the role of dose-rate remains unclear. Further experience is needed before definitive conclusions can be drawn.

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